GRA 14, a novel dense granule protein from Neospora caninum
نویسندگان
چکیده
منابع مشابه
GRA 14, a novel dense granule protein from Neospora caninum.
Dense granule protein (GRA) is a secreted protein in Neospora caninum and Toxoplasma gondii, which plays an important role in forming parasitophorous vacuole (PV) [1–4]. GRAs are thought to remodel and maintain the environment of the PV for intracellular survival and replication in T. gondii [5]. The precise function of GRAs is still unknown [6–9]. TgGRA14 protein is a new GRA protein that it i...
متن کاملFirst Characterization of the Neospora caninum Dense Granule Protein GRA9
The obligate intracellular apicomplexan parasite Neospora caninum (N. caninum) is closely related to Toxoplasma gondii (T. gondii). The dense granules, which are present in all apicomplexan parasites, are important secretory organelles. Dense granule (GRA) proteins are released into the parasitophorous vacuole (PV) following host cell invasion and are known to play important roles in the mainte...
متن کاملImmunization with oligomannose-coated liposome-entrapped dense granule protein 7 protects dams and offspring from Neospora caninum infection in mice.
The present study demonstrates that the subcutaneous administration of Neospora caninum dense granule protein 7 (NcGRA7) entrapped in liposomes coated with mannotriose strongly induces the parasite-specific T-helper type 1 immune response and humoral antibody in mice. Although anti-NcGRA7 immunoglobulin G1 antibody production was induced in mice injected with NcGRA7 alone, the dams and offsprin...
متن کاملDense-granule protein NcGRA7, a new marker for the serodiagnosis of Neospora caninum infection in aborting cows.
To investigate whether the production of an antigen-specific antibody is associated with Neospora caninum-induced bovine abortion, 62 serum samples were tested with an enzyme-linked immunosorbent assay using the recombinant antigens NcSAG1, NcSRS2, and NcGRA7. Our study suggested that NcGRA7 would be a new marker for the serodiagnosis of N. caninum infection resulting in abortion.
متن کاملNeospora caninum and neosporosis
Neospora caninum is a protozoan cyst forming apicomplexan parasite that causes neosporosis, notably in cattle (Bos taurus) and domestic dogs (Canis familiaris) [1,2]. It is closely related to Toxoplasma gondii and has emerged as a major cause of reproductive failure in cattle worldwide [2]. The parasite was first described in a dog with encephalomyelitis and myositis [1] and was later described...
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ژورنال
عنوان ژورنال: Acta Biochimica et Biophysica Sinica
سال: 2013
ISSN: 1745-7270,1672-9145
DOI: 10.1093/abbs/gmt036